Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Joanne Attema
PROVIDER: E-GEOD-18669 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20091103 2
Heritable epigenetic signatures are proposed to serve as an important regulatory mechanism in lineage fate determination. To investigate this, we profiled chromatin modifications in murine hematopoietic stem cells, lineage-restricted progenitors, and CD4(+) T cells using modified genome-scale mini-chromatin immunoprecipitation technology. We show that genes involved in mature hematopoietic cell function associate with distinct chromatin states in stem and progenitor cells, before their activatio ...[more]