Genome-wide DNA methylation profiling of Acute Myeloid Leukemia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maria Figueroa
PROVIDER: E-GEOD-18700 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.
Figueroa Maria E ME Lugthart Sanne S Li Yushan Y Erpelinck-Verschueren Claudia C Deng Xutao X Christos Paul J PJ Schifano Elizabeth E Booth James J van Putten Wim W Skrabanek Lucy L Campagne Fabien F Mazumdar Madhu M Greally John M JM Valk Peter J M PJ Löwenberg Bob B Delwel Ruud R Melnick Ari A
Cancer cell 20100107 1
We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtype ...[more]
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