Dataset Information
Murine lung tumors- HER2(V659E) and KRAS(G12V) vs normal lung
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: James Abraham
PROVIDER: E-GEOD-18784 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas.
Nature biotechnology 20091220 1
To recapitulate the stochastic nature of human cancer development, we have devised a strategy for generating mouse tumor models that involves stepwise genetic manipulation of embryonic stem (ES) cells and chimera generation. Tumors in the chimeric animals develop from engineered cells in the context of normal tissue. Adenocarcinomas arising in an allelic series of lung cancer models containing HER2 (also known as ERBB2), KRAS or EGFR oncogenes exhibit features of advanced malignancies. Treatment ...[more]
