Unknown,Transcriptomics,Genomics,Proteomics

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Murine lung tumors- HER2(V659E) and KRAS(G12V) vs normal lung


ABSTRACT: Transcriptiional profling of 13 normal lung samples, 18 lung KRAS(G12V) tumor samples, and 18 lung HER2(V659E) tumor samples 13 normal lung samples, 18 lung KRAS(G12V) tumor samples, and 18 lung HER2(V659E) tumor samples hybridized against Stratagene universal mouse reference RNA with dye swap

ORGANISM(S): Mus musculus

SUBMITTER: James Abraham 

PROVIDER: E-GEOD-18784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


To recapitulate the stochastic nature of human cancer development, we have devised a strategy for generating mouse tumor models that involves stepwise genetic manipulation of embryonic stem (ES) cells and chimera generation. Tumors in the chimeric animals develop from engineered cells in the context of normal tissue. Adenocarcinomas arising in an allelic series of lung cancer models containing HER2 (also known as ERBB2), KRAS or EGFR oncogenes exhibit features of advanced malignancies. Treatment  ...[more]

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