Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of mouse oviduct, uterus and vagina treated with DES from new born mice to understand the mechanism of the differentiation of female reproductive tracts


ABSTRACT: Diethylstilbestrol (DES) inhibits the differentiation of female reproductive tracts during fetal and neonatal days . We examined global gene expressions in the oviduct, uterus and vagina in newborn mice with or without DES. These results suggest understanding the mechanism of the differentiation of female reproductive tracts. Keywords: ordered

ORGANISM(S): Mus musculus

SUBMITTER: Atsuko Suzuki 

PROVIDER: E-GEOD-1886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression change in the Müllerian duct of the mouse fetus exposed to diethylstilbestrol in utero.

Suzuki Atsuko A   Urushitani Hiroshi H   Sato Tomomi T   Kobayashi Tomohiro T   Watanabe Hajime H   Ohta Yasuhiko Y   Iguchi Taisen T  

Experimental biology and medicine (Maywood, N.J.) 20070401 4


In utero exposure to diethylstilbestrol (DES) induces various abnormalities in the Müllerian duct of the mouse. In order to understand the underlying molecular mechanisms associated with DES-induced abnormalities of the Müllerian duct, gene expression was examined on Gestation Day (GD) 19 in mouse fetuses exposed to DES (67 microg/kg body weight) from GDs 10 to 18. Microarray analysis revealed that 387, 387, and 225 genes were upregulated and 177, 172, and 75 genes were downregulated by DES in t  ...[more]

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