Effects of IGF 1 on primary breast fibroblasts (normal and carcinoma associated)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michal Rajski
PROVIDER: E-GEOD-18952 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients.
Rajski Michal M Zanetti-Dällenbach Rosanna R Vogel Brigitte B Herrmann Richard R Rochlitz Christoph C Buess Martin M
BMC medicine 20100105
<h4>Background</h4>Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately.<h4>Methods</h4>We used an ex vivo culture model and measured gene expression changes after IGF-I stimulation with cDNA microarrays. In vitro data were correlated with in vivo findings by comparing the results with ...[more]
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