Unknown,Transcriptomics,Genomics,Proteomics

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Endogenous short RNAs in Mucor circinelloides sequenced on the Illumina platform (Solexa)


ABSTRACT: We sequenced Endogenous short RNAs in Mucor circinelloides fungus grown in standard liquid culture. Short RNAs were profiled in wild type, Dicer-like 1 mutant (dcl1-), Dicer-like 2 mutant (dcl2-) and double Dicer mutant (dcl1-/dcl2-) strains. We identified many loci that produced less short RNAs in the dcl2- strain suggesting that DCL2 is the major protein generating short RNAs in Mucor circinelloides. Endogenous short RNAs were profiled in wild type, single and double dcl mutant strains.

ORGANISM(S): Mucor circinelloides

SUBMITTER: Simon Moxon 

PROVIDER: E-GEOD-18958 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides.

Nicolas Francisco Esteban FE   Moxon Simon S   de Haro Juan P JP   Calo Silvia S   Grigoriev Igor V IV   Torres-Martínez Santiago S   Moulton Vincent V   Ruiz-Vázquez Rosa M RM   Dalmay Tamas T  

Nucleic acids research 20100428 16


Endogenous short RNAs (esRNAs) play diverse roles in eukaryotes and usually are produced from double-stranded RNA (dsRNA) by Dicer. esRNAs are grouped into different classes based on biogenesis and function but not all classes are present in all three eukaryotic kingdoms. The esRNA register of fungi is poorly described compared to other eukaryotes and it is not clear what esRNA classes are present in this kingdom and whether they regulate the expression of protein coding genes. However, evidence  ...[more]

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