Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: CBDM Lab
PROVIDER: E-GEOD-1921 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Goldrath Ananda W AW Luckey C John CJ Park Richard R Benoist Christophe C Mathis Diane D
Proceedings of the National Academy of Sciences of the United States of America 20041117 48
Naïve T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by ...[more]