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Transcription profiling of mouse OTI CD8 T cells transferred to irradiated syngeneic hosts


ABSTRACT: A time course of OTI CD8 T cells transferred to irradiated syngeneic hosts (or unirradiated hosts as control).

ORGANISM(S): Mus musculus

SUBMITTER: CBDM Lab 

PROVIDER: E-GEOD-1921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The molecular program induced in T cells undergoing homeostatic proliferation.

Goldrath Ananda W AW   Luckey C John CJ   Park Richard R   Benoist Christophe C   Mathis Diane D  

Proceedings of the National Academy of Sciences of the United States of America 20041117 48


Naïve T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by  ...[more]

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