Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yuriy Orlov
PROVIDER: E-GEOD-19219 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Han Jianyong J Yuan Ping P Yang Henry H Zhang Jinqiu J Soh Boon Seng BS Li Pin P Lim Siew Lan SL Cao Suying S Tay Junliang J Orlov Yuriy L YL Lufkin Thomas T Ng Huck-Hui HH Tam Wai-Leong WL Lim Bing B
Nature 20100207 7284
Induced pluripotent stem (iPS) cells can be obtained by the introduction of defined factors into somatic cells. The combination of Oct4 (also known as Pou5f1), Sox2 and Klf4 (which we term OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts. These cells are thought to resemble embryonic stem cells (ESCs) on the basis of global gene expression analyses; however, few studies have tested the ability and efficiency of iPS cells to contribute to chimaeri ...[more]