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Activation of ER-alpha network in MMTV-Wnt/ILK mammary tumors

ABSTRACT: A transgenic mouse model, MMTV-Wnt/ILK, with mammary specific expression of both Wnt-1 and ILK, was generated by crossing the two mouse lines MMTV-Wnt-1 and MMTV-ILK. Affymetrix Mouse Exon chips were hybridized with material from four independent mammary tumors from each MMTV-Wnt-1 and MMTV-Wnt/ILK transgenic model, in order to identify possible signaling differences involved during increased tumor incidence. One-way ANOVA: MMTV-Wnt vs. MMTV-Wnt/ILK

ORGANISM(S): Mus musculus

SUBMITTER: Samuel Aparicio

PROVIDER: E-GEOD-19300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of ER-alpha network in MMTV-Wnt/ILK mammary tumors

Project description:A transgenic mouse model, MMTV-Wnt/ILK, with mammary specific expression of both Wnt-1 and ILK, was generated by crossing the two mouse lines MMTV-Wnt-1 and MMTV-ILK. Affymetrix Mouse Exon chips were hybridized with material from four independent mammary tumors from each MMTV-Wnt-1 and MMTV-Wnt/ILK transgenic model, in order to identify possible signaling differences involved during increased tumor incidence.

2010-06-16 | GSE19300 | GEO

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Project description:Activation of ER-alpha network in MMTV-Wnt/ILK mammary tumors

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Expression data from Integrin-linked kinase (ILK)-deficient epidermis

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Changes in Gene expression during the development and progression of mammary tumors in MMTV-Wnt-1 and MMTV-Neu TG mice

Project description:Gene expression profiling of samples from normal virgin mammary glands, hyperplastic mammary glands, mamary tumors, and lung metastases from MMTV-Wnt-1 transgenic (TG) mice, and mammary tumors and lung metastases from MMTV-Neu trangenic (TG) mice Keywords: Array analysis, multi-step tumorigenesis, metastasis, MMTV-Wnt-1 trangenic mice, MMTV-Neu transgenic mice

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RNA sequencing of ILK-deficient hair follicle bulge stem cells

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An ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma.

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