Unknown,Transcriptomics,Genomics,Proteomics

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Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair-2


ABSTRACT: Dkk4 transgenic mice in Tabby background lack hair follicle formation. Gene expression profiling showed significant down regulation of Shh pathway genes at E16.5 and E17.5, the secondary hair follicle induction stages. Keywords: development or differentiation design,genetic modification design To define target genes of Dkk4 during secondary hair follicle induction, we carried out microarray experiments with mouse back skin samples that from 2 developmental time points including E16.5 and E17.5 of Tabby and Tabby background Dkk4 transgenic mice.

ORGANISM(S): Mus musculus

SUBMITTER: Minoru Ko 

PROVIDER: E-GEOD-19312 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair.

Cui Chang-Yi CY   Kunisada Makoto M   Piao Yulan Y   Childress Victoria V   Ko Minoru S H MS   Schlessinger David D  

PloS one 20100401 4


The mouse hair coat comprises protective "primary" and thermo-regulatory "secondary" hairs. Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair. We report that Dickkopf 4 (Dkk4), a Wnt antagonist, affects an auxiliary pathway for Eda-independent development of secondary hair. A Dkk4 transgene in wild-type mice had no effect on primary hair, but secondary hairs were severely malformed. Dkk4 action on secondary hair  ...[more]

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