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Expression data from pediatric primary intracranial germ cell tumor

ABSTRACT: Intracranial pediatric germ cell tumors (GCTs) have different histological differentiations, prognosis and clinical behaviors. Prognosis of patients with germinoma and mature teratoma is good, while patients with other types of GCTs, termed as nongerminomatous malignant germ cell tumors (NGMGCTs), require more extensive drug and irradiation treatment regimen. The mechanisms underlying different prognosis of various GCT subgroups remain elusive. We presented a distinct mRNA profile correlating with GCT histological differentiation and prognosis. 13 central nervous system GCT cases with different histological subtypes are subjected to transcriptome analysis. The histological subtypes are germinoma, mixed GCT of germinoma and mature teratoma , immature teratoma , mixed GCTs of NGMGCTs category, yolk sac tumor, immature teratoma, and embryonal carcinoma.

ORGANISM(S): Homo sapiens

SUBMITTER: Hsei-Wei Wang 

PROVIDER: E-GEOD-19348 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations.

Wang Hsei-Wei HW   Wu Yu-Hsuan YH   Hsieh Jui-Yu JY   Liang Muh-Lii ML   Chao Meng-En ME   Liu Da-Jung DJ   Hsu Ming-Ta MT   Wong Tai-Tong TT  

BMC genomics 20100224

<h4>Background</h4>Intracranial pediatric germ cell tumors (GCTs) are rare and heterogeneous neoplasms and vary in histological differentiation, prognosis and clinical behavior. Germinoma and mature teratoma are GCTs that have a good prognosis, while other types of GCTs, termed nongerminomatous malignant germ cell tumors (NGMGCTs), are tumors with an intermediate or poor prognosis. The second group of tumors requires more extensive drug and irradiation treatment regimens. The mechanisms underlyi  ...[more]

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