Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Loris De Cecco
PROVIDER: E-GEOD-19352 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Iorio Egidio E Ricci Alessandro A Bagnoli Marina M Pisanu Maria Elena ME Castellano Giancarlo G Di Vito Massimo M Venturini Elisa E Glunde Kristine K Bhujwalla Zaver M ZM Mezzanzanica Delia D Canevari Silvana S Podo Franca F
Cancer research 20100223 5
Altered phosphatidylcholine (PC) metabolism in epithelial ovarian cancer (EOC) could provide choline-based imaging approaches as powerful tools to improve diagnosis and identify new therapeutic targets. The increase in the major choline-containing metabolite phosphocholine (PCho) in EOC compared with normal and nontumoral immortalized counterparts (EONT) may derive from (a) enhanced choline transport and choline kinase (ChoK)-mediated phosphorylation, (b) increased PC-specific phospholipase C (P ...[more]