Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human fibroblasts grown on TCPS plates, Collagen-GAG 2 D plate and Collagen-GAG 3D mesh


ABSTRACT: All mRNA was isolated after 8 hours of culture time in each of three culture conditions. (1) TCPS Plate, (2) Collagen-GAG 2 dimensional coated plate and (3) collagen-GAG three dimensional mesh.

ORGANISM(S): Homo sapiens

SUBMITTER: Catherine Klapperich 

PROVIDER: E-GEOD-1937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Fibroblast remodeling activity at two- and three-dimensional collagen-glycosaminoglycan interfaces.

Jaworski Justyn J   Klapperich Catherine M CM  

Biomaterials 20060418 23


Previously we demonstrated that high throughput gene expression experiments can yield novel information about how cells respond to a collagen-glycosaminoglycan (GAG) three-dimensional culture environment. The goal of the current study was to determine which of these differences result from culture in a three-dimensional construct versus those caused simply by the presence of the collagen-GAG biomaterial. To make this distinction, cells were cultured both in collagen-GAG scaffolds fabricated usin  ...[more]

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