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Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved sequence elements

ABSTRACT: The manuscript by D. Licastro and colleagues “Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved sequence elements” presents an overview of experimental and computational approaches employed by the authors to perform a multi-facet characterization of ultraconserved elements (UCEs). The authors present an interesting analysis where they investigate the transcription of UCEs in mouse development at different stages by conductin an microarray experiment. Some of these results are further verified by RT-PCR. 12 Samples, 4 groups 3 samples per group.

ORGANISM(S): Mus musculus

SUBMITTER: Danilo Licastro

PROVIDER: E-GEOD-19371 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elements.

Licastro Danilo D Gennarino Vincenzo A VA Petrera Francesca F Sanges Remo R Banfi Sandro S Stupka Elia E

BMC genomics 20100304

<h4>Background</h4>Ultraconserved elements (UCEs) are highly constrained elements of mammalian genomes, whose functional role has not been completely elucidated yet. Previous studies have shown that some of them act as enhancers in mouse, while some others are expressed in both normal and cancer-derived human tissues. Only one UCE element so far was shown to present these two functions concomitantly, as had been observed in other isolated instances of single, non ultraconserved enhancer elements ...[more]

PMID: 20202189

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