Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anne Schaefer
PROVIDER: E-GEOD-19402 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schaefer Anne A Sampath Srihari C SC Intrator Adam A Min Alice A Gertler Tracy S TS Surmeier D James DJ Tarakhovsky Alexander A Greengard Paul P
Neuron 20091201 5
The genetic basis of cognition and behavioral adaptation to the environment remains poorly understood. Here we demonstrate that the histone methyltransferase complex GLP/G9a controls cognition and adaptive responses in a region-specific fashion in the adult brain. Using conditional mutagenesis in mice, we show that postnatal, neuron-specific deficiency of GLP/G9a leads to derepression of numerous nonneuronal and neuron progenitor genes in adult neurons. This transcriptional alteration is associa ...[more]