Unknown,Transcriptomics,Genomics,Proteomics

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CLL Patients


ABSTRACT: Genomic profiles of CLL (Chronic Lymphocytic Leukemia) patients. 11 CLL patients were selected for detection of genomic aberrations, 8 patients with atypical CLL and 3 patients with typical CLL. Patient's DNA were hybridized against Promega control on Agilent G4410A arrays and scanned with the Agilent G2505B scanner.

ORGANISM(S): Homo sapiens

SUBMITTER: Xavier Troussard 

PROVIDER: E-GEOD-19458 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Array-based comparative genomic hybridization (aCGH) is a powerful tool to detect genomic imbalances in the human genome. The analysis of aCGH data sets has revealed the existence of a widespread technical artifact termed as 'waves', characterized by an undulating data profile along the chromosome. Here, we describe the development of a novel noise-reduction algorithm, waves aCGH correction algorithm (WACA), based on GC content and fragment size correction. WACA efficiently removes the wave arti  ...[more]

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