Ontology highlight
ABSTRACT:
ORGANISM(S): Plasmodium falciparum
SUBMITTER: Balbir Chaal
PROVIDER: E-GEOD-19468 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hu Guangan G Cabrera Ana A Kono Maya M Mok Sachel S Chaal Balbir K BK Haase Silvia S Engelberg Klemens K Cheemadan Sabna S Spielmann Tobias T Preiser Peter R PR Gilberger Tim-W TW Bozdech Zbynek Z
Nature biotechnology 20091227 1
Functions have yet to be defined for the majority of genes of Plasmodium falciparum, the agent responsible for the most serious form of human malaria. Here we report changes in P. falciparum gene expression induced by 20 compounds that inhibit growth of the schizont stage of the intraerythrocytic development cycle. In contrast with previous studies, which reported only minimal changes in response to chemically induced perturbations of P. falciparum growth, we find that approximately 59% of its c ...[more]