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Gene epression profile in human BM-MSC

ABSTRACT: Gene expression profiles of human BM-MSC isolated form normal donor to elucidate potential molecular network for clinical application Fresh isolated BM-MSC cells were cultured on defined condition. Functional assay was performed prior to gene expression analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Jui-Yu Hsieh 

PROVIDER: E-GEOD-19471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Functional network reconstruction reveals somatic stemness genetic maps and dedifferentiation-like transcriptome reprogramming induced by GATA2.

Huang Tse-Shun TS   Hsieh Jui-Yu JY   Wu Yu-Hsuan YH   Jen Chih-Hung CH   Tsuang Yang-Hwei YH   Chiou Shih-Hwa SH   Partanen Jukka J   Anderson Heidi H   Jaatinen Taina T   Yu Yau-Hua YH   Wang Hsei-Wei HW  

Stem cells (Dayton, Ohio) 20080228 5

Somatic stem cell transplantation holds great promise in regenerative medicine. The best-characterized adult stem cells are mesenchymal stem cells (MSCs), neural stem cells (NSCs), and CD133(+) hematopoietic stem cells (HSCs). The applications of HSCs are hampered since these cells are difficult to maintain in an undifferentiated state in vitro. Understanding genes responsible for stem cell properties and their interactions will help on this issue. The construction of stem cell genetic networks  ...[more]

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