Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

49 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene epression profile in human BM-MSC

ABSTRACT: Gene expression profiles of human BM-MSC isolated form normal donor to elucidate potential molecular network for clinical application Fresh isolated BM-MSC cells were cultured on defined condition. Functional assay was performed prior to gene expression analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Jui-Yu Hsieh

PROVIDER: E-GEOD-19471 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Functional network reconstruction reveals somatic stemness genetic maps and dedifferentiation-like transcriptome reprogramming induced by GATA2.

Huang Tse-Shun TS Hsieh Jui-Yu JY Wu Yu-Hsuan YH Jen Chih-Hung CH Tsuang Yang-Hwei YH Chiou Shih-Hwa SH Partanen Jukka J Anderson Heidi H Jaatinen Taina T Yu Yau-Hua YH Wang Hsei-Wei HW

Stem cells (Dayton, Ohio) 20080228 5

Somatic stem cell transplantation holds great promise in regenerative medicine. The best-characterized adult stem cells are mesenchymal stem cells (MSCs), neural stem cells (NSCs), and CD133(+) hematopoietic stem cells (HSCs). The applications of HSCs are hampered since these cells are difficult to maintain in an undifferentiated state in vitro. Understanding genes responsible for stem cell properties and their interactions will help on this issue. The construction of stem cell genetic networks ...[more]

PMID: 18308945

Similar Datasets

Expression data from five independent murine BM MSC

Project description:Data collected in our laboratory show that independent murine MSC cultures react in a heterogeneous manner to Toll-like receptors (TLRs) activation. This array aims to investigate the molecular basis for the heterogeneity in the response of MSCs to TLR activation and its origin. For this array, 5 MSC preparation, all from BM of female C57BL/6J 6-8 weeks old, were studied in two replicates.

2016-07-03 | E-GEOD-50560 | biostudies-arrayexpress

Gene epression profile in human BM-MSC

Project description:Gene expression profiles of human BM-MSC isolated form normal donor to elucidate potential molecular network for clinical application

2010-10-02 | GSE19471 | GEO

MicroRNA expression profiling of extracellular vesicles derived from human BM-MSC

Project description:Human MSC are tissue stem cells that show multiple biological effects. At the present, how BM-MSC exert their effects are not fully understood. In this study, a novel cell-cell communication mediator, extraxellular vesicles (EV), were examined in the involvement of BM-MSC-mediated biological effects.

2018-05-21 | GSE99082 | GEO

Transcriptional Alterations in Bone Marrow Mesenchymal Stromal Cells derived from Acute Myeloid Leukemia patients (AML BM-MSC)

Project description:The aim of the study was to get insights into transcriptional alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients We compared the global gene expression profile from AML BM-MSC (n=19) to healthy donor (HD) controls (HD BM-MSC n=4)

2016-07-27 | GSE84881 | GEO

Gene expression profiles of LEC, MLC-L, and MSC-BM

Project description:Gene expression profiles of limbal explant culture-derived epithelial (LEC) and mesenchymal-like cells (MLC-L) and bone marrow-derived mesenchymal stem cells (MSC-BM). To confirm the stem cell signatures of cultured LEC and to establish the source, possible role of the stroma-derived MLC-L .

2009-11-01 | GSE16763 | GEO

Molecular alterations in bone marrow mesenchymal stromal cells (BM-MSC) derived from acute myeloid leukemia patients (AML)

Project description:Genome wide methylation profiling of BM-MSC derived from AML patients in comparison to healthy donor controls using Illumina Infinium HumanMethylation450 Beadchip

2016-03-30 | GSE79695 | GEO

Expression data from Bone-Marrow Mesenchymal Stromal Cells (BM-MSC) from Follicular Lymphoma patient (FL) or Healthy Donor (HD).

Project description:Human bone marrow mesenchymal stromal cells (BM-MSC) could be committed toward a functional lymphoid-like stroma by a combination of TNFalpha (TNF) and Lymphotoxin alpha1/beta2 (LT) (Amé-Thomas et al Blood 2007). Bone marrow and lymph node stromal cells support FL malignant cell recruitment and growth in particular after comittment to a lymphoid-like differentiation in vitro. In addition, more than 70% of FL patients exhibit a bone marrow involvment at diagnosis. We delineate using Affymetrix U133+2.0 microarrays the gene expression profile of BM-MSC obtained from FL patients (FL-MSC) and age-matched healthy donors (HD-MSC) in order to identify a specific FL-MSC signature. In addition, we used Affymetrix microarrays to define the gene expression signature of lymphoid-like stromal cells obtained from HD-MSC by treatment with TNF/LT in vitro. This TNF/LT signature was then used to interpret the gene expression profile of FL-MSC.

2012-01-26 | GSE35331 | GEO

BM-eGFP+ MSC expression arrays

Project description:original population (oMSC) and highly migrative subpopulation (sMSC) of murine eGFP+ bone marrow MSC

| EGAD00010001265 | EGA

Myeloma cancer cells can corrupt mesenchymal stromal senescent cells and impair their anti-tumor activity

Project description:Senescent cells secrete many molecules, which contribute to the prevention of cancer progression. We induced MSC senescence by oxidative stress, DNA damage, and replicative exhaustion. The first two are considered inducers of acute senescence while extensive proliferation triggers replicative senescence also named chronic senescence. We cultivated cancer cells in the presence of acute and chronic senescent MSC conditioned media and evaluated proliferation, DNA damage, apoptosis and senescence.

2018-10-25 | PXD003018 | Pride

Transcriptome profile in the human synovial MSC-aggregates

Project description:One of strategies to regenerate cartilage defect is transplantation of mesenchymal stem cells (MSCs). Improvements of therapeutic potential of MSCs are needed to achieve successful cartilage regeneration by transplantation of a limited number of cells. Aggregated culture is a popular method in ES and iPS cells to maintain or enhance their potentials. Here we investigated gene expression profile of aggregated MSCs. 621 genes were up-regulated and 409 genes were down-regulated more than 5-fold in MSC-aggregates compared with the number in MSCs in a monolayer culture. The most up-regulated gene was BMP2, which is one of the genes involved in chondrogenesis. Anti-inflammatory genes were also up-regulated in MSC-aggregates. The microarray data for selected genes were confirmed by real-time PCR. Human synovial MSCs was isolated from synovium of 3 distinct donors. The gene expression profile of MSC-aggregates cultured in hanging drop for 3days was compared with that of MSCs in a monolayer culture.

2012-05-12 | E-GEOD-31980 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data