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The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation


ABSTRACT: This study was to elucidate the molecular mechanisms on delayed implantation in a global perspective through the combination of global microRNAs (miRNAs) and mRNA expression analysis in mouse uterus through Solexa sequencing. Examination of m/miRNA expression in mouse uterus.

ORGANISM(S): Mus musculus

SUBMITTER: Zeng-Ming Yang 

PROVIDER: E-GEOD-19473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation.

Su Ren-Wei RW   Lei Wei W   Liu Ji-Long JL   Zhang Zhi-Rong ZR   Jia Bo B   Feng Xu-Hui XH   Ren Gang G   Hu Shi-Jun SJ   Yang Zeng-Ming ZM  

PloS one 20101129 11


<h4>Background</h4>Delayed implantation is a developmental arrest at the blastocyst stage and a good model for embryo implantation. MicroRNAs (miRNAs) have been shown to be involved in mouse embryo implantation through regulating uterine gene expression. This study was to have an integrative analysis on global miRNA and mRNA expression in mouse uterus under delayed implantation and activation through Illumina sequencing.<h4>Methodology/principal findings</h4>By deep sequencing and analysis, we f  ...[more]

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