Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profling of infants (<1 year of age) diagnosed with Acute Lymphoblastic Leukemia (ALL) characterised by genomic translocation.


ABSTRACT: Acute Lymphoblastic Leukemia (ALL) in infants (<1 year) is characterized by a poor prognosis and a high incidence of MLL translocations. Several studies demonstrated the unique gene expression profile associated with MLL-rearranged ALL, but generally small cohorts were analyzed as uniform patient groups regardless of the type of MLL translocation, while the analysis of translocation-negative infant ALL remained unacknowledged. We generated and analyzed primary infant ALL expression profiles (n=73) typified by translocations t(4;11), t(11;19) and t(9;11), or the absence of MLL translocations, in order to study translocation-specific gene expression between the different genetic subtypes of infant ALL.

ORGANISM(S): Homo sapiens

SUBMITTER: Ronald Stam 

PROVIDER: E-GEOD-19475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale.

Stumpel D J P M DJ   Schotte D D   Lange-Turenhout E A M EA   Schneider P P   Seslija L L   de Menezes R X RX   Marquez V E VE   Pieters R R   den Boer M L ML   Stam R W RW  

Leukemia 20101130 3


MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (<1 year) is the most aggressive type of childhood leukemia. To develop more suitable treatment strategies, a firm understanding of the biology underlying this disease is of utmost importance. MLL-rearranged ALL displays a unique gene expression profile, partly explained by erroneous histone modifications. We recently showed that t(4;11)-positive infant ALL is also characterized by pronounced promoter CpG hypermethylation. In this stud  ...[more]

Publication: 1/2

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