Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ronald Stam
PROVIDER: E-GEOD-19475 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stumpel D J P M DJ Schotte D D Lange-Turenhout E A M EA Schneider P P Seslija L L de Menezes R X RX Marquez V E VE Pieters R R den Boer M L ML Stam R W RW
Leukemia 20101130 3
MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (<1 year) is the most aggressive type of childhood leukemia. To develop more suitable treatment strategies, a firm understanding of the biology underlying this disease is of utmost importance. MLL-rearranged ALL displays a unique gene expression profile, partly explained by erroneous histone modifications. We recently showed that t(4;11)-positive infant ALL is also characterized by pronounced promoter CpG hypermethylation. In this stud ...[more]