Transcriptome analysis reveals a major impact of Tyk2 on the expression of interferon responsive and metabolic genes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Claus Vogl
PROVIDER: E-GEOD-19733 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.
Vogl Claus C Flatt Thomas T Fuhrmann Bernd B Hofmann Elisabeth E Wallner Barbara B Stiefvater Rita R Kovarik Pavel P Strobl Birgit B Müller Mathias M
BMC genomics 20100325
<h4>Background</h4>Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment. However, how Tyk2 globally regulates transcription of downstream target genes remains unknown. Here we e ...[more]
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