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Effect of Diabetes on Retinal Müller Cells


ABSTRACT: Rat Retinal Müller cells from diabetic rats (diabetes duration 6 months) compared to Rat Retinal Müller cells from healthy rats. Diabetes was induced by streptozotozine. Diabetic rats were treated with small doses of insulin to prevent catabolism. Keywords: ordered

ORGANISM(S): Rattus norvegicus

SUBMITTER: Chiara Gerhardinger 

PROVIDER: E-GEOD-1979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expression of acute-phase response proteins in retinal Müller cells in diabetes.

Gerhardinger Chiara C   Costa Montserrat Biarnés MB   Coulombe Mary C MC   Toth Ildiko I   Hoehn Todd T   Grosu Paul P  

Investigative ophthalmology & visual science 20050101 1


<h4>Purpose</h4>To characterize the whole spectrum of gene expression changes induced by diabetes in retinal Müller glial cells.<h4>Methods</h4>Müller cells were isolated from the retina of streptozotocin-diabetic and age-matched control rats by gradient centrifugation and immediately processed for RNA isolation. The gene expression profile of Müller cells was studied with the GeneChip Rat Genome oligonucleotide array (Affymetrix, Santa Clara, CA). The upregulation of acute-phase proteins in the  ...[more]

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