Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Antoine Peters
PROVIDER: E-GEOD-19892 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa.
Brykczynska Urszula U Hisano Mizue M Erkek Serap S Ramos Liliana L Oakeley Edward J EJ Roloff Tim C TC Beisel Christian C Schübeler Dirk D Stadler Michael B MB Peters Antoine H F M AH
Nature structural & molecular biology 20100516 6
In higher eukaryotes, histone methylation is involved in maintaining cellular identity during somatic development. As most nucleosomes are replaced by protamines during spermatogenesis, it is unclear whether histone modifications function in paternal transmission of epigenetic information. Here we show that two modifications important for Trithorax- and Polycomb-mediated gene regulation have methylation-specific distributions at regulatory regions in human spermatozoa. Histone H3 Lys4 dimethylat ...[more]
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