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Expression profiling of liver tissue from C57BL6 x DBA strain

ABSTRACT: Expression profiling of liver tissue from 111 F2 female mice resulting from a cross between C57BL/6J and DBA/2J inbred mouse strains. Mice were feed a chow diet for 12 months followed by 4 months on an atherogenic high-fat, high-cholesterol diet. Parental and F2 mice were killed at 16 months of age. The livers were removed immediately and flash frozen for expression profiling. See Schadt, et al., Nature , Vol 422(6929):297-302 for details. Keywords = Genetics of Gene Expression Keywords = mouse Keywords = C57BL6 Keywords = DBA

ORGANISM(S): Mus musculus

SUBMITTER: Eric Schadt

PROVIDER: E-GEOD-2008 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetics of gene expression surveyed in maize, mouse and man.

Schadt Eric E EE Monks Stephanie A SA Drake Thomas A TA Lusis Aldons J AJ Che Nam N Colinayo Veronica V Ruff Thomas G TG Milligan Stephen B SB Lamb John R JR Cavet Guy G Linsley Peter S PS Mao Mao M Stoughton Roland B RB Friend Stephen H SH

Nature 20030301 6929

Treating messenger RNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been pursued in gene-specific ways. Transcript abundances often serve as a surrogate for classical quantitative traits in that the levels of expression are significantly correlated with the classical traits across members of a segregating population. The correlation structure between transcript abundances and classical traits has been used to identify susce ...[more]

PMID: 12646919

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Expression profiling of liver tissue from C57BL6 x DBA strain

Project description:Expression profiling of liver tissue from 111 F2 female mice resulting from a cross between C57BL/6J and DBA/2J inbred mouse strains. Mice were feed a chow diet for 12 months followed by 4 months on an atherogenic high-fat, high-cholesterol diet. Parental and F2 mice were killed at 16 months of age. The livers were removed immediately and flash frozen for expression profiling. See Schadt, et al., Nature , Vol 422(6929):297-302 for details. Keywords = Genetics of Gene Expression Keywords = mouse Keywords = C57BL6 Keywords = DBA Keywords: repeat sample

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