Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

44 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression analysis of dissected Globus Pallidus interna in Parkinson's disease

ABSTRACT: Genome-wide transcriptome analysis of expression changes in Globus Pallidus interna (GPi) from Parkinson's disease brain tissue versus control brain tissue. Post-mortem brain expression analysis performed in 10 PD brain samples and 10 control brain samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Davis

PROVIDER: E-GEOD-20146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Expression analysis of dissected GPi in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in Globus Pallidus interna (GPi) from Parkinson's disease brain tissue versus control brain tissue.

2010-02-04 | GSE20146 | GEO

Expression analysis of laser-dissected SNpc neurons in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue. Post-mortem brain expression analysis performed in 10 PD brain samples and 8 control brain samples.

2010-02-22 | E-GEOD-20141 | biostudies-arrayexpress

Transcriptional analysis of multiple brain regions in Parkinson's disease

Project description:Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional analysis of prefrontal area 9 in Parkinson's disease GSE20291: Transcriptional analysis of putamen in Parkinson's disease GSE20292: Transcriptional analysis of whole substantia nigra in Parkinson's disease Refer to individual Series

2010-03-23 | E-GEOD-20295 | biostudies-arrayexpress

Transcriptional analysis of prefrontal area 9 in Parkinson's disease

Project description:Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects Published work contains more information on Parkinson and Control groups

2010-02-22 | E-GEOD-20168 | biostudies-arrayexpress

Transcriptional analysis of putamen in Parkinson's disease

2010-03-23 | E-GEOD-20291 | biostudies-arrayexpress

Transcriptional analysis of whole substantia nigra in Parkinson's disease

2010-03-23 | E-GEOD-20292 | biostudies-arrayexpress

Expression analysis of laser-dissected SNpc neurons in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue.

2010-02-04 | GSE20141 | GEO

A Single-Cell Atlas of Cell Types, States, and Other Transcriptional Patterns from Nine Regions of the Adult Mouse Brain

Project description:We report 690K single-cell transcriptomes from nine different brain regions from adult mice (Frontal and Posterior Cortex, Hippocampus, Thalamus, Cerebellum, Striatum, Globus Pallidus externus/Nucleus Basalis, Entopeduncular / Subthalamic Nuclei, & Substantia Nigra / Ventral Tegmental Area).

2018-08-22 | GSE116470 | GEO

Expression analysis of lymphoblast cells lines in Parkinson's disease

Project description:Genome-wide transcriptome analysis of expression changes in EBV transformed cell lines from the Coriell Cell Repository in Parkinson and Control subjects. 8 Parkinson cell lines versus 8 control cell lines.

2010-02-22 | E-GEOD-20153 | biostudies-arrayexpress

Cell type-specific oxidative stress genomic signatures in the globus pallidus of dopamine depleted mice

Project description:We developed a new viral affinity purification strategy, Cre-Specific Nuclear Anchored Independent Labeling (cSNAIL), to isolate Cre recombinase-expressing (Cre+) nuclei from the adult mouse brain. cSNAIL is an AAV that delivers a modified version of the nuclear-anchored protein tag developed for INTACT nuclei isolation (Deal & Henikoff, Dev Cell. 2010. 18:1030-1040; Mo et al., Neuron. 2015. 86(6):1369-1384). Applying cSNAIL technology in Pvalb-2A-Cre mice, we performed targeted assessment of the cell type-specific transcriptomic and epigenetic effects of dopamine depletion on parvalbumin-expressing (PV+) neurons and PV- nuclei. We recovered signatures of oxidative stress response involving Hif2a signaling that was specific to external globus pallidus (GPe) PV+ neurons, a consequence of dopamine depletion that may have theraputic implications for Parkinson's disease.

2020-09-07 | GSE157359 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data