Unknown,Transcriptomics,Genomics,Proteomics

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ATF3 is a positive regulator of human IFN gene expression


ABSTRACT: The aim of this study was to identify genes regulated by IL-12, IL-18 and IFN-alpha during early differentiation of human Th1 cells Human cord blood CD4+ T cells were activated via TCR and cultured in the presence of IL-12, IFN-alpha or IL-12+IL-18. Cytokine induced gene expression was compared to activation only after 2h, 6h or 48h of cell culture. 12 samples were analyzed in total.

ORGANISM(S): Homo sapiens

SUBMITTER: Sanna Filén 

PROVIDER: E-GEOD-20198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Activating transcription factor 3 is a positive regulator of human IFNG gene expression.

Filén Sanna S   Ylikoski Emmi E   Tripathi Subhash S   West Anne A   Björkman Mari M   Nyström Joel J   Ahlfors Helena H   Coffey Eleanor E   Rao Kanury V S KV   Rasool Omid O   Lahesmaa Riitta R  

Journal of immunology (Baltimore, Md. : 1950) 20100319 9


IL-12 and IL-18 are essential for Th1 differentiation, whereas the role of IFN-alpha in Th1 development is less understood. In this microarray-based study, we searched for genes that are regulated by IFN-alpha, IL-12, or the combination of IL-12 plus IL-18 during the early differentiation of human umbilical cord blood CD4(+) Th cells. Twenty-six genes were similarly regulated in response to treatment with IL-12, IFN-alpha, or the combination of IL-12 plus IL-18. These genes could therefore play  ...[more]

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