Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Sanna Filén
PROVIDER: E-GEOD-20198 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Filén Sanna S Ylikoski Emmi E Tripathi Subhash S West Anne A Björkman Mari M Nyström Joel J Ahlfors Helena H Coffey Eleanor E Rao Kanury V S KV Rasool Omid O Lahesmaa Riitta R
Journal of immunology (Baltimore, Md. : 1950) 20100319 9
IL-12 and IL-18 are essential for Th1 differentiation, whereas the role of IFN-alpha in Th1 development is less understood. In this microarray-based study, we searched for genes that are regulated by IFN-alpha, IL-12, or the combination of IL-12 plus IL-18 during the early differentiation of human umbilical cord blood CD4(+) Th cells. Twenty-six genes were similarly regulated in response to treatment with IL-12, IFN-alpha, or the combination of IL-12 plus IL-18. These genes could therefore play ...[more]