Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Owen McCann
PROVIDER: E-GEOD-20236 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rakyan Vardhman K VK Down Thomas A TA Maslau Siarhei S Andrew Toby T Yang Tsun-Po TP Beyan Huriya H Whittaker Pamela P McCann Owen T OT Finer Sarah S Valdes Ana M AM Leslie R David RD Deloukas Panogiotis P Spector Timothy D TD
Genome research 20100310 4
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery cohort, and then replicate these aDMRs in sorted CD4(+) T-cells and CD14(+) monocytes in an independent cohort, suggesting that aDMRs occur in precursor haematopoietic cells. Further replication of th ...[more]