Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrew Oler
PROVIDER: E-GEOD-20309 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Oler Andrew J AJ Alla Ravi K RK Roberts Douglas N DN Wong Alexander A Hollenhorst Peter C PC Chandler Katherine J KJ Cassiday Patrick A PA Nelson Cassie A CA Hagedorn Curt H CH Graves Barbara J BJ Cairns Bradley R BR
Nature structural & molecular biology 20100425 5
RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs) important for translational capacity and other functions. We localized Pol III, alternative TFIIIB complexes (BRF1 or BRF2) and TFIIIC in HeLa cells to determine the Pol III transcriptome, define gene classes and reveal 'TFIIIC-only' sites. Pol III localization in other transformed and primary cell lines reveals previously uncharacterized and cell type-specific Pol III loci as well as one microRNA. Notably, onl ...[more]