Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Andrei Krivtsov
PROVIDER: E-GEOD-20377 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:We generated MLL-AF9 mediated murine leukemias that originate either from hematopoietic stem or committed progenitors cells. The luekemia stem cell fraction in these two type of leukemias shared exactly the same immunophenotype but their genetic programs differ. Total RNA from HSC(KLS), CMP, MEP, and GMP, and from leukemia stem cells (LGMP) was isolated and hybridized to Affymetrix expresison microarrays.
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