Expression Profiling of a Genetic Animal Model of Depression
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Adam Taylor
PROVIDER: E-GEOD-20388 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.
Blaveri Ekaterini E Kelly Fiona F Mallei Alessandra A Harris Kriss K Taylor Adam A Reid Juliet J Razzoli Maria M Carboni Lucia L Piubelli Chiara C Musazzi Laura L Racagni Girogio G Mathé Aleksander A Popoli Maurizio M Domenici Enrico E Bates Stewart S
PloS one 20100907 9
<h4>Background</h4>The Flinders model is a validated genetic rat model of depression that exhibits a number of behavioural, neurochemical and pharmacological features consistent with those observed in human depression.<h4>Principal findings</h4>In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and control Flinders Depression Resistant (FRL) lines to understand molecular basis for the diff ...[more]
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Project description:Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-like Behaviours In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and control Flinders Depression Resistant (FRL) lines to understand molecular basis for the differences between the two lines. We profiled two independent cohorts of Flinders animals derived from the same colony six months apart, each cohort statistically powered to allow independent as well as combined analysis. Using this approach, we were able to validate using real-time-PCR a core set of gene expression differences that showed statistical significance in each of the temporally distinct cohorts, representing consistently maintained features of the model.
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