Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rolf Marschalek
PROVIDER: E-GEOD-20519 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bursen Adelheid A Schwabe Karen K Rüster Brigitte B Henschler Reinhard R Ruthardt Martin M Dingermann Theo T Marschalek Rolf R
Blood 20100301 17
The chromosomal translocation t(4;11)(q21;q23) is the most frequent genetic aberration of the human MLL gene, resulting in high-risk acute lymphoblastic leukemia (ALL). To elucidate the leukemogenic potential of the fusion proteins MLL.AF4 and AF4.MLL, Lin(-)/Sca1(+) purified cells (LSPCs) were retrovirally transduced with either both fusion genes or with MLL.AF4 or AF4.MLL alone. Recipients of AF4.MLL- or double-transduced LSPCs developed pro-B ALL, B/T biphenotypic acute leukemia, or mixed lin ...[more]