Blood Gene Expression Signatures Predict Invasive Candidiasis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hamza Aziz
PROVIDER: E-GEOD-20524 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Blood gene expression signatures predict invasive candidiasis.
Zaas Aimee K AK Aziz Hamza H Lucas Joseph J Perfect John R JR Ginsburg Geoffrey S GS
Science translational medicine 20100301 21
Candidemia is the fourth most common bloodstream infection, with Candida albicans being the most common causative species. Success in reducing the associated morbidity and mortality has been limited by the inadequacy and time delay of currently available diagnostic modalities. Focusing on host response to infection, we used a murine model to develop a blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from Staphylococcus aureus bacteremia ...[more]
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