PBECs stimulated with pro-inflammatory cytokines and P. aeruginosa
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joost Vos
PROVIDER: E-GEOD-2056 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense.
Vos Joost B JB van Sterkenburg Marianne A MA Rabe Klaus F KF Schalkwijk Joost J Hiemstra Pieter S PS Datson Nicole A NA
Physiological genomics 20050208 3
The airway epithelium responds to microbial exposure by altering expression of a variety of genes to increase innate host defense. We aimed to delineate the early transcriptional response in human primary bronchial epithelial cells exposed for 6 h to a mixture of IL-1beta and TNF-alpha or heat-inactivated Pseudomonas aeruginosa. Because molecular mechanisms of epithelial innate host defense are not fully understood, the open-ended expression-profiling technique SAGE was applied to construct gene ...[more]
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