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The mutation spectrum revealed by paired genome sequences from a lung cancer patient

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE20574: Agilent 244A aCGH array for comparison of lung tumor CNA to high-throughput sequencing data GSE20578: Assessment of mutation on expression levels GSE20584: Affymetrix SNP6.0 array for comparison of lung tumor and adjacent normal to high-throughput sequencing data Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Haverty

PROVIDER: E-GEOD-20585 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient.

Lee William W Jiang Zhaoshi Z Liu Jinfeng J Haverty Peter M PM Guan Yinghui Y Stinson Jeremy J Yue Peng P Zhang Yan Y Pant Krishna P KP Bhatt Deepali D Ha Connie C Johnson Stephanie S Kennemer Michael I MI Mohan Sankar S Nazarenko Igor I Watanabe Colin C Sparks Andrew B AB Shames David S DS Gentleman Robert R de Sauvage Frederic J FJ Stern Howard H Pandita Ajay A Ballinger Dennis G DG Drmanac Radoje R Modrusan Zora Z Seshagiri Somasekar S Zhang Zemin Z

Nature 20100501 7297

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell lung carcinomas in smokers being the predominant form of the disease. Although previous studies have identified important common somatic mutations in lung cancers, they have primarily focused on a limited set of genes and have thus provided a constrained view of the mutational spectrum. Recent cancer sequencing efforts have used next-generation sequencing technologies to provide a genome-wide view of muta ...[more]

PMID: 20505728

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