Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide identification of putative cis-regulatory elements through epigenetic profiling in zebrafish


ABSTRACT: In this study, we have applied ChIP-Seq to identify putative regulatory elements throughout the zebrafish genome. For this purpose we identified sequences within the zebrafish genome that associate with H3K4me1 and H3K4me3, which are epigenetic modifications known to be associated with active cis-regulatory elements in other species. Determination of H3K4me1- and H3K4me3-binding sites in the zebrafish genome.

ORGANISM(S): Danio rerio

SUBMITTER: Lihua Zhu 

PROVIDER: E-GEOD-20600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites.

Aday Aaron W AW   Zhu Lihua Julie LJ   Lakshmanan Abirami A   Wang Jie J   Lawson Nathan D ND  

Developmental biology 20110322 2


An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs essential for cellular function. The genome also harbors cis-acting non-coding sequences that control gene expression and are essential to coordinate regulatory programs during embryonic development. However, the genome sequence is largely identical between cell types within a multi-cellular organism indicating that factors such as DNA accessibility and chromatin structure play a crucial role in governing ce  ...[more]

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