Unknown,Transcriptomics,Genomics,Proteomics

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VCAM1 promotes outbreak from dormant bone metastasis

ABSTRACT: A weakly bone metastatic variant of the breast cancer cell line MDA-MB-231, SCP6, gave rise to highly bone metastatic sublines (PD1, PD2A-E) after long time dormancy in vivo. These cell lines were subjected to microarray analysis with data drawn from previous studies (Kang et al., 2003; Minn et al. 2005; Lu and Kang 2009; Lu and Kang 2010). Keywords: Cell type comparison 12 cell lines (parental MDA-MB-231 with biological repeats; weakly bone metastasis variants: SCP3, SCP4 and SCP6; post-dormancy sublines of SCP6: PD1, PD2A, PD2B, PD2C, PD2D, PD2E and PD2R) were cultured and subjected to Affymetrix microarray analysis. Data were analysed with Genespring software.

ORGANISM(S): Homo sapiens

SUBMITTER: Yibin Kang 

PROVIDER: E-GEOD-20611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.

Lu Xin X   Mu Euphemia E   Wei Yong Y   Riethdorf Sabine S   Yang Qifeng Q   Yuan Min M   Yan Jun J   Hua Yuling Y   Tiede Benjamin J BJ   Lu Xuemin X   Haffty Bruce G BG   Pantel Klaus K   Massagué Joan J   Kang Yibin Y  

Cancer cell 20111201 6

Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer. Here, we characterize a bone metastasis dormancy model to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-κB pathway, promotes the transition from indolent micrometastasis to overt metastasis. By interacti  ...[more]