Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Louise Showe
PROVIDER: E-GEOD-20613 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Negorev Dmitri G DG Vladimirova Olga V OV Kossenkov Andrew V AV Nikonova Elena V EV Demarest Renee M RM Capobianco Anthony J AJ Showe Michael K MK Rauscher Frank J FJ Showe Louise C LC Maul Gerd G GG
Cancer research 20101130 23
Identifying the functions of proteins, which associate with specific subnuclear structures, is critical to understanding eukaryotic nuclear dynamics. Sp100 is a prototypical protein of ND10/PML nuclear bodies, which colocalizes with Daxx and the proto-oncogenic PML. Sp100 isoforms contain SAND, PHD, Bromo, and HMG domains and are highly sumoylated, all characteristics suggestive of a role in chromatin-mediated gene regulation. A role for Sp100 in oncogenesis has not been defined previously. Usin ...[more]