Endothelial cells and exposure to enviromental tobacco
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: John Maresh
PROVIDER: E-GEOD-2090 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo.
Maresh J Gregory JG Xu Huaxia H Jiang Nan N Gairola C Gary CG Shohet Ralph V RV
Physiological genomics 20050222 3
We hypothesized that human smoking and its deleterious effects on endothelial function can be modeled by exposure of mice to tobacco smoke, and further that these changes would be reflected in gene regulation in vascular endothelium. We used for these studies a mouse strain that expresses green fluorescent protein under the control of an endothelial-specific promoter, Tie-2. Mice were exposed to sidestream smoke from reference cigarettes at 34 mg total suspended particulates/m3. After exposure f ...[more]
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