Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Louis Staudt
PROVIDER: E-GEOD-20988 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rui Lixin L Emre N C Tolga NC Kruhlak Michael J MJ Chung Hye-Jung HJ Steidl Christian C Slack Graham G Wright George W GW Lenz Georg G Ngo Vu N VN Shaffer Arthur L AL Xu Weihong W Zhao Hong H Yang Yandan Y Lamy Laurence L Davis R Eric RE Xiao Wenming W Powell John J Maloney David D Thomas Craig J CJ Möller Peter P Rosenwald Andreas A Ott German G Muller-Hermelink Hans Konrad HK Savage Kerry K Connors Joseph M JM Rimsza Lisa M LM Campo Elias E Jaffe Elaine S ES Delabie Jan J Smeland Erlend B EB Weisenburger Dennis D DD Chan Wing C WC Gascoyne Randy D RD Levens David D Staudt Louis M LM
Cancer cell 20101201 6
Chromosome band 9p24 is frequently amplified in primary mediastinal B cell lymphoma (PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened an RNA interference library targeting amplicon genes and thereby identified JAK2 and the histone demethylase JMJD2C as essential genes in these lymphomas. Inhibition of JAK2 and JMJD2C cooperated in killing these lymphomas by decreasing tyrosine 41 phosphorylation and increasing lysine 9 trimethylation of histone H3, promoting h ...[more]