MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate

ABSTRACT: Current knowledge of prostate cancer genomes is largely based on relatively small patient cohorts using single modality analysis platforms. Here we report concordant assessment of DNA copy number, mRNA and microRNA expression and focused exon resequencing in prostate tumors from 218 patients with primary or metastatic prostate cancer with a median of 5 years clinical follow-up, now made available as a public resource. Mutations in known, commonly mutated oncogenes and tumor suppressor genes such as PIK3CA, KRAS, BRAF and TP53 are present but generally rare. However, integrative analysis of mutations with copy number alterations (CNAs) and expression changes reveal alterations in the PI3K, RAS/RAF and androgen receptor (AR) pathways in nearly all metastatic samples and in a higher frequency

ORGANISM(S): Homo sapiens

SUBMITTER: Barry Taylor 

PROVIDER: E-GEOD-21036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress