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Transcription profiling of rat kidney from spontaneously hypertensive animals

ABSTRACT: Affymetrix RG U34A analysis of renal gene expression in Wistar-derived rat strains

ORGANISM(S): Rattus norvegicus

SUBMITTER: Peter Doris

PROVIDER: E-GEOD-2104 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes.

Hinojos Cruz A CA Boerwinkle Eric E Fornage Myriam M Doris Peter A PA

Hypertension (Dallas, Tex. : 1979) 20050214 4

Allelic expression in genes has become recognized as a heritable trait by which phenotypes are generated. We have examined gene expression in the rat kidney using genome-wide microarray technology (Affymetrix). Gene expression was determined across 4 rat strains, 3 hypertensive spontaneously hypertensive rat (SHR) substrains (SHR-A3, SHR-B2, and SHR-C), and a normotensive strain (Wistar-Kyoto [WKY]). Expression measurements were made in multiple animals from all strains at 4 time points (4 weeks ...[more]

PMID: 15710778

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