Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcriptome analysis of miR-144/451-null bone marrow erythroid cells


ABSTRACT: microRNA miR-144/451 is highly expressed during erythropoiesis. We deleted the miR-144/451 gene locus in mice and compared the transcriptomes of miR-144/451-null bone marrow erythroid precursors to stage-matched wild-type control cells. Ter119+/CD71+/FSC-high bone marrow erythroblasts were sorted directly into Trizol LS reagent. Total RNAs extracted from three miR-144/451 knock-out and three wide type mice were analyzed using Affymetrix Mouse Genome 430 2.0 Arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Duonan Yu 

PROVIDER: E-GEOD-21041 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


The bicistronic microRNA (miRNA) locus miR-144/451 is highly expressed during erythrocyte development, although its physiological roles are poorly understood. We show that miR-144/451 ablation in mice causes mild erythrocyte instability and increased susceptibility to damage after exposure to oxidant drugs. This phenotype is deeply conserved, as miR-451 depletion synergizes with oxidant stress to cause profound anemia in zebrafish embryos. At least some protective activities of miR-451 stem from  ...[more]

Similar Datasets

2010-07-15 | GSE21041 | GEO
2018-08-08 | GSE118249 | GEO
2023-01-13 | GSE208608 | GEO
2022-05-11 | GSE202260 | GEO
2018-10-01 | GSE104447 | GEO
2018-10-01 | GSE104441 | GEO
2018-10-01 | GSE104357 | GEO
| PRJNA484955 | ENA
2013-09-11 | E-GEOD-50742 | biostudies-arrayexpress
| PRJNA860212 | ENA