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Massive decrease of maternal polyA mRNA upon post-ovulatory aging in Xenopus tropicalis

ABSTRACT: We used microarrays to detail the global gene expression changes following aging of oocytes We compared fresh oocytes with post-ovulatory aged oocytes by microarray analysis

ORGANISM(S): Xenopus (Silurana) tropicalis

SUBMITTER: Ludger Klein-Hitpass

PROVIDER: E-GEOD-21109 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Aging of Xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mRNAs and loss of developmental potential.

Kosubek Anna A Klein-Hitpass Ludger L Rademacher Katrin K Horsthemke Bernhard B Ryffel Gerhart U GU

PloS one 20101022 10

As first shown more than 100 years ago, fertilization of an aged (overripe) egg increases the rate of malformations and embryonic loss in several vertebrates, including possibly humans as well. Since the molecular events in aging eggs may be similar in these species, we established in the frog Xenopus tropicalis a defined protocol for delayed fertilization of eggs. A three-hour delayed fertilization led to a dramatic increase in malformation and mortality. Gene expression profiling revealed that ...[more]

PMID: 21042572

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Massive decrease of maternal polyA mRNA upon post-ovulatory aging in Xenopus tropicalis

Project description:We used microarrays to detail the global gene expression changes following aging of oocytes

2011-03-29 | GSE21109 | GEO

High-throughput sequencing of small RNAs from Xenopus tropicalis

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Proteogenomics of Candida tropicalis – an opportunistic pathogen

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2017-05-08 | PXD001071 | Pride

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Stable intronic sequence RNA (sisRNA), a new class of noncoding RNA from the oocyte nucleus of Xenopus tropicalis

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Protein kinase C-beta dependent activation of NF-kB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia in B-cells in vivo.

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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