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Transcription profiling of human bronchial epithelial cells treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.

ABSTRACT: Human bronchial epithelial cells were treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Yuh-Chin Tony Huang

PROVIDER: E-GEOD-2111 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells.

Li Zhuowei Z Stonehuerner Jackie J Devlin Robert B RB Huang Yuh-Chin T YC

Environmental health perspectives 20051201 12

We hypothesized that gene expression profiling may discriminate vanadium from zinc in human bronchial epithelial cells (HBECs). RNA from HBECs exposed to vehicle, V (50 microM), or Zn (50 microM) for 4 hr (n = 4 paired experiments) was hybridized to Affymetrix Hu133A chips. Using one-class t-test with p < 0.01, we identified 140 and 76 genes with treatment:control ratios > or = 2.0 or < or = 0.5 for V and Zn, respectively. We then categorized these genes into functional pathways and compared the ...[more]

PMID: 16330358

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