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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat left ventricular samples from 12-, 16- and 20-month old spontaneously hypertensive rats (SHRs) compared with age-matched Wistar-Kyoto (WKY) rats as controls

ABSTRACT: Left ventricular gene expression profiles from 12-, 16- and 20-months old spontaneously hypertensive rats (SHRs) were compared with left ventricular profiles seen in age-matched Wistar-Kyoto (WKY) rats [control rats] by screening Affymetrix U34A arrays (there are 4 samples in each timepoint except 3 samples of 20-months old WKYs).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jaana RysÃ¤

PROVIDER: E-GEOD-2116 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Distinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure.

Rysä Jaana J Leskinen Hanna H Ilves Mika M Ruskoaho Heikki H

Hypertension (Dallas, Tex. : 1979) 20050418 5

Cardiac hypertrophy in response to pressure overload is initially beneficial but eventually leads to heart failure, a major cause of morbidity and mortality in the Western countries. Although abnormalities in left ventricular (LV) diastolic filling are early features associated with pressure overload-induced LV hypertrophy, the molecular mechanisms regulating transition to diastolic heart failure are poorly understood. We analyzed global changes in gene expression in 12-, 16-, and 20-month-old s ...[more]

PMID: 15837839

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SHR-WKY

Project description:Left ventricular gene expression profiles from 12-, 16- and 20-months old spontaneously hypertensive rats (SHRs) were compared with left ventricular profiles seen in age-matched Wistar-Kyoto (WKY) rats by screening Affymetrix U34A arrays (there are 4 samples in each timepoint except 3 samples of 20-months old WKYs). Keywords: time-course

2005-07-01 | GSE2116 | GEO

Transcription profiling of rat adrenal glands from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto animals

Project description:We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA.

2007-11-01 | E-GEOD-1675 | biostudies-arrayexpress

Transcription profiling of feft ventricle in three genetic rat models of hypertension

Project description:Left ventricle gene expression was analyzed in three models of hypertension in order to clarify the molecular mechanisms associated with left ventricular hypertrophy. Transgenic heterozygous TGR(mRen2)27 rats, overexpressing the mouse renin gene, and their littermate negative controls, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY), and Lyon hypertensive rats (LH) and their normotensive controls (LL) were included in the study.

2006-08-31 | E-MEXP-357 | biostudies-arrayexpress

RNA-seq of early pregnant (GD6.5) or non-pregnant uterine arteries from stroke-prone spontaneously hypertensive (SHRSP) and wistar kyoto (WKY) rats

Project description:Chronic hypertension during pregnancy affects both mother and infant but its pathological mechanisms are unclear. Due to ethical limitations human data is available in term tissue only- so deeper understanding of the vascular changes during early pregnancy are unknown. This study utilises a known rat model of chronic hypertension to study changes in gene expression at an early gestational time point. After 6 days of pregnancy animals were sacrificed and main uterine arteries harvested for RNA-Seq (or age-matched virgin rats as controls).

2021-03-15 | E-MTAB-10212 | biostudies-arrayexpress

Transcription profiling of Dahl salt-sensitive and salt-resistant congenic rats

Project description:Kidney samples from three Dahl Salt-sensitive S rats were compared with kidney samples from three S.R(9)x3A congenic rats.

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Downregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.

Project description:The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, a quantitative trait locus (QTL) influencing blood pressure, left ventricular mass and heart interstitial fibrosis was genetically isolated within 788 kb on chromosome 8 segment of SHR-PD5 congenic strain that contains only 7 genes, including mutant Plzf (promyelocytic leukemia zinc finger) gene. To identify Plzf as a quantitative trait gene, we targeted Plzf in the SHR using the TALEN technique and obtained SHR line harboring mutant Plzf gene with a premature stop codon at position of amino acid 58. The Plzf mutant allele is semi-lethal since approximately 95% of newborn homozygous animals die perinatally due to multiple developmental abnormalities. Heterozygous rats were grossly normal and were used for metabolic and hemodynamic analyses. SHR-Plzf+/- heterozygotes versus SHR wild type controls exhibited reduced body weight and relative weight of epididymal fat, lower serum and liver triglycerides and cholesterol and better glucose tolerance. In addition, SHR-Plzf+/- rats exhibited significantly increased sensitivity of adipose and muscle tissue to insulin action when compared to wild type controls. Blood pressure was comparable in SHR versus SHR-Plzf+/-, however, there was significant amelioration of cardiomyocyte hypertrophy and cardiac fibrosis in SHR-Plzf+/- rats. Gene expression profiles in the liver and expression of selected genes in the heart revealed differentially expressed genes playing a role in metabolic pathways, PPAR signaling, and cell cycle regulation. These results provide evidence for an important role of Plzf in regulation of metabolic and cardiac traits in the rat and suggest a cross-talk between cell cycle regulators, metabolism, cardiac hypertrophy and fibrosis.

2016-07-03 | E-MTAB-3831 | biostudies-arrayexpress

Rats, heart tissue, iTRAQ proteomics

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2020-04-23 | PXD017765 | Pride

Gene expression profiling of Bone-Marrow-Derived-Macrophages (5 days of culture) in a backcross population of LEW and WKY

Project description:WKY and LEW strains have been widely studied for their differential susceptibility to experimental glomerulonephritis. In particular these strains show strong variations in the macrophage activation. This dataset measures expression of macrophages in backcross population of WKY DC and LEW rats and includes a few control origninating from the WKY DC strain.

2014-08-31 | E-MTAB-2719 | biostudies-arrayexpress

Obesity impact on the left ventricular transcriptome of 4 and 10 months old SHHF rats

Project description:Impact of the obesity on RNA total levels of male SHHF left ventricular aged from 4 and 10 months old. Keywords: Comparative cDNA hybridization

2006-07-05 | GSE2876 | GEO

Regulation of gene expression with thyorid hormone in rats with myocardial infarction

Project description:Thyroid hormone improves left ventricular remodeling and cardiac performance after myocardial infarction (MI), but the molecular basis is unknown. This study was designed to detect gene expression changes in left ventricular non-infarcted areas at 4 weeks following myocardial infarction with and without thyroid hormone treatment. The results suggest that altered expression of genes for molecular function and biological process may be involved in the beneficial effects of thyroid hormone treatment following myocardial infarction in rats. MI was produced by ligation of the left anterior descending coronary artery in female SD rats. Rats were divided into the following groups: (1) Sham MI, (2) MI, and (3) MI+T4 treatment (T4 pellet 3.3mg, 60 days release, implanted subcutaneously immediately following MI). Four weeks after surgery, total RNA was isolated from left ventricular non-infarcted areas for microarray analysis using the Illumina RatRef-12 Expression BeadChip Platform.

2012-04-30 | E-GEOD-35088 | biostudies-arrayexpress

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