Unknown,Transcriptomics,Genomics,Proteomics

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Developmental Regulation and Individual Differences of Neuronal Epigenomes in the Prefrontal Cortex


ABSTRACT: We report global distribution of trimethylated Histone H3 Lysine 4 (H3K4me3) in human prefrontal cortex neurons at different ages Neuronal nuclei from human prefrontal cortex were isolated by FACS. Regions marked by H3K4me3 were identified by chromatin immunoprecipiation followed by deep sequencing.

ORGANISM(S): Homo sapiens

SUBMITTER: Hennady Shulha 

PROVIDER: E-GEOD-21172 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex.

Cheung Iris I   Shulha Hennady P HP   Jiang Yan Y   Matevossian Anouch A   Wang Jie J   Weng Zhiping Z   Akbarian Schahram S  

Proceedings of the National Academy of Sciences of the United States of America 20100426 19


Little is known about the regulation of neuronal and other cell-type specific epigenomes from the brain. Here, we map the genome-wide distribution of trimethylated histone H3K4 (H3K4me3), a mark associated with transcriptional regulation, in neuronal and nonneuronal nuclei collected from prefrontal cortex (PFC) of 11 individuals ranging in age from 0.5 to 69 years. Massively parallel sequencing identified 12,732-19,704 H3K4me3 enriched regions (peaks), the majority located proximal to (within 2  ...[more]

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