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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse lymph nodes treated with soluble lymphotoxin-beta receptor for 0, 1, 2, 3, 27 and 35 days

ABSTRACT: treatment of mesenteric lymph nodes with soluble lymphotoxin-beta receptor for 0,1,2,3,27 and 35 days

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Huber

PROVIDER: E-GEOD-2124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes.

Huber Christoph C Thielen Caroline C Seeger Harald H Schwarz Petra P Montrasio Fabio F Wilson Mark R MR Heinen Ernst E Fu Yang-Xin YX Miele Gino G Aguzzi Adriano A

Journal of immunology (Baltimore, Md. : 1950) 20050501 9

Affinity maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT beta receptor (LTbetaR) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expr ...[more]

PMID: 15843551

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Project description:treatment of mesenteric lymph nodes with soluble lymphotoxin-beta receptor for 0,1,2,3,27 and 35 days Keywords: time-course

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Expression data from pig mesenteric lymph nodes

Project description:The mesenteric lymph nodes represent the immune response to eggs in schistosome infections,and the analysis of gene expression profiles of the mesenteric lymph nodes from the Vac-Cha (vaccinated with UV attenuated cercariae and challenged with normal cercariae)and Inf-Con (infected with normal cercariae) groups. We used microarrays to detail the global programme of gene expression and identified distinct classes of up-regulated and down-regulated genes. The mesenteric lymph nodes surrounding the cecum from the Vac-Cha and Inf-Con groups were collected at week 8 post challenge and used to analyze the gene profile with Affymetrix microarrays. We sought to obtain the different genes expression profiles between the Vac-Cha group and Inf-Con group.The Vac-Cha group is three pigs vaccinated with UV attenuated Schistosoma japonicum cercariae and challenged with normal Schistosoma japonicum cercariae, and the Inf-Con group is three pigs infected with normal cercariae. Samples pooled per group. A list of differentially-regulated genes can be found in the supplementary file below.

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