Dataset Information
Transcription profiling of liver tissue from Txnip-deficient mice with hepatocellular carcinoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): hepatocellular carcinoma
SUBMITTER: Sonal Suresh Sheth
PROVIDER: E-GEOD-2127 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hepatocellular carcinoma in Txnip-deficient mice.
Oncogene 20060410 25
The molecular pathogenesis and the genetic aberrations that lead to the progression of hepatocellular carcinoma (HCC) are largely unknown. Here, we demonstrate that the thioredoxin interacting protein (Txnip) gene is a candidate tumor suppressor gene in vivo. We previously showed that the recombinant inbred congenic strain HcB-19 has a spontaneous mutation of the Txnip gene, and we now show that the strain has dramatically increased incidence of HCC, and that the HCC cosegregates with the Txnip ...[more]
