Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: James Granneman
PROVIDER: E-GEOD-2130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
American journal of physiology. Endocrinology and metabolism 20050607 4
Selective agonists of beta(3)-adrenergic receptors (Adrb3) exhibit potent anti-diabetes properties in rodent models when given chronically, yet the mechanisms involved are poorly understood. A salient feature of chronic Adrb3 activation is pronounced remodeling of white adipose tissue (WAT), which includes mitochondrial biogenesis and elevation of metabolic rate. To gain insights into potential mechanisms underlying WAT remodeling, the time course of remodeling induced by the Adrb3 agonist CL-31 ...[more]