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Transcription profiling of mouse epididymal white adipose tissue from C57Bl6 strain after treatment with 3nmol/hr CL 316243 - time series

ABSTRACT: TIme course of gene expression changes in epididymal white adipose tissue of 3-4 month old male Bl6 mice treated with CL 316243 for 0,1,3 or 6 days

ORGANISM(S): Mus musculus

SUBMITTER: James Granneman

PROVIDER: E-GEOD-2130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation.

Granneman James G JG Li Pipeng P Zhu Zhengxian Z Lu Yuyan Y

American journal of physiology. Endocrinology and metabolism 20050607 4

Selective agonists of beta(3)-adrenergic receptors (Adrb3) exhibit potent anti-diabetes properties in rodent models when given chronically, yet the mechanisms involved are poorly understood. A salient feature of chronic Adrb3 activation is pronounced remodeling of white adipose tissue (WAT), which includes mitochondrial biogenesis and elevation of metabolic rate. To gain insights into potential mechanisms underlying WAT remodeling, the time course of remodeling induced by the Adrb3 agonist CL-31 ...[more]

PMID: 15941787

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C57Bl6 3nmol/hr CL 316243 Time course

Project description:TIme course of gene expression changes in epididymal white adipose tissue of 3-4 month old male Bl6 mice treated with CL 316243 for 0,1,3 or 6 days Keywords: time-course

2005-06-10 | GSE2130 | GEO

Mus musculus musculus isolate:epididymal White Adipose Tissue

Project description:Mus musculus musculus isolate:epididymal White Adipose Tissue Transcriptome or Gene expression

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Gene expression in mouse epididymal white adipose tissue in response to short-term calorie restriction

Project description:The effect of a short-term calorie restricted diet was evaluated in epididymal white adipose tissue (WAT) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

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Epididymal Adipose Tissue Profiling In HMDP

Project description:Identify genes in the epididymal adipose tissue whose expression is under genetic regulation in the hybrid mouse diversity panel. The hybrid mouse diversity panel is comprised of classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Bennett et al Genome Research 2010. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness. GWAS for expression of epididymal adipose tissue in inbred strains

2013-01-09 | E-GEOD-42890 | biostudies-arrayexpress

Castration-induced changes in mouse epididymal white adipose tissue.

Project description:We analyzed the effects of castration on epididymal white adipose tissue (WAT) in C57BL/6J mice which were fed a regular or high-fat diet. Fourteen days following surgical castration profound effects on WAT tissue such as reductions in WAT wet weight and WAT/body weight ratio, induction of lipolysis and morphologic changes characterized by smaller adipocytes, and increased stromal cell compartment were documented in both dietary groups. Castrated animals had decreased serum leptin levels independent of diet but diet-dependent decreases in serum adiponectin and resistin. The castrated high-fat group had dramatically lower serum triglyceride levels. Immunohistochemical analysis revealed higher staining for smooth muscle actin, macrophage marker Mac-3, and Cxcl5 in the castrated than in the control mice in both dietary groups. We also detected increased fatty-acid synthase expression in the stromal compartment of WAT in the regular-diet group. Castration also reduces the expression of androgen receptor in WAT in the regular-diet group. We conclude that castration reduces tissue mass and affects biologic function of WAT in mice.

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Expression data from mice epididymal adipose tissue

Project description:Visceral white adipose tissue is closed correlated with obesity and metabolic dysfunction. Epididymal adipose tissue (eWAT) is considered as typical visceral white adipose tissue. Induction of browning of white adipose tissue improves metabolic dysfunction such as insulin resistance. In contrast to mice subcutaneous adipose tissue, visceral fat do not show significant browning under 4°C. However,under physiologically tolerable low temperature visceral adipose tissue can turn brown. We used microarrays to detail the global programme of gene expression in C57Bl/6 mice epididymal adipose tissue exposed to thermoneutral 30°C, 4°C and temperatures lower than 4°C.

2017-06-12 | GSE74062 | GEO

Transcription profiling of murine epididymal adipose tissue

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Mouse expression data of epididymal white adipose tissue at Zeitgeber time (ZT) 18 comparison control vs. Sleep restriction

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Project description:Functional genomic analysis of epididymal adipose tissue extracted from polygenic obese mice fed either a control (1% linoleic acid) or treatment (1% trans 10, cis 12 conjugated linoleic acid) diet after five or fourteen days. Keywords = Obesity Keywords = conjugated linoleic acid Keywords = polygenic obese mice Keywords = adiposity Keywords = lipid metabolism Keywords = apoptosis Keywords: repeat sample

2004-07-23 | GSE1580 | GEO

Transcription profiling of Ercc1 white adipose tissue

Project description:Transcriptome analysis of epididymal white adipose tissue (WAT) depots in Ercc1 animals: To further elucidate the role of ERCC1 in WAT we scanned the transcriptome of 15 day old wt and Ercc1 epididymal WAT.

2013-11-04 | E-MEXP-3930 | biostudies-arrayexpress

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