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Transcription profiling of mouse epididymal white adipose tissue from C57Bl6 strain after treatment with 3nmol/hr CL 316243 - time series


ABSTRACT: TIme course of gene expression changes in epididymal white adipose tissue of 3-4 month old male Bl6 mice treated with CL 316243 for 0,1,3 or 6 days

ORGANISM(S): Mus musculus

SUBMITTER: James Granneman 

PROVIDER: E-GEOD-2130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation.

Granneman James G JG   Li Pipeng P   Zhu Zhengxian Z   Lu Yuyan Y  

American journal of physiology. Endocrinology and metabolism 20050607 4


Selective agonists of beta(3)-adrenergic receptors (Adrb3) exhibit potent anti-diabetes properties in rodent models when given chronically, yet the mechanisms involved are poorly understood. A salient feature of chronic Adrb3 activation is pronounced remodeling of white adipose tissue (WAT), which includes mitochondrial biogenesis and elevation of metabolic rate. To gain insights into potential mechanisms underlying WAT remodeling, the time course of remodeling induced by the Adrb3 agonist CL-31  ...[more]

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