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Transcription profiling of white adipose tissue from wild type and Ppara KO mice treated with the adrb3 agonist CL 316243 to understand the metabolic and cellular plasticity in the tissue.

ABSTRACT: Time course of gene expression changes in white fat of wildtype and Ppara KO mice during treatment with the adrb3 agonist CL 316243.

ORGANISM(S): Mus musculus

SUBMITTER: James Granneman

PROVIDER: E-GEOD-2131 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-alpha.

Li Pipeng P Zhu Zhengxian Z Lu Yuyan Y Granneman James G JG

American journal of physiology. Endocrinology and metabolism 20050607 4

Chronic activation of adipocyte beta-adrenergic receptors induces remodeling of white adipose tissue (WAT) that includes a transient inflammatory response followed by mitochondrial biogenesis, induction of fatty acid oxidation genes, and elevation of tissue oxidative metabolism. Gene profiling experiments of WAT during remodeling induced by the beta(3)-adrenergic receptor agonist CL-316,243 (CL) suggested that peroxisome proliferator-activated receptor-alpha (Ppara), which is upregulated by CL, ...[more]

PMID: 15941786

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